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LRG1 GTPase-activating protein LRG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851358, updated on 4-Jan-2025

Summary

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Official Symbol
LRG1
Official Full Name
GTPase-activating protein LRG1
Primary source
SGD:S000002399
Locus tag
YDL240W
See related
AllianceGenome:SGD:S000002399; FungiDB:YDL240W; VEuPathDB:YDL240W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in several processes, including negative regulation of Rho protein signal transduction; regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP1 (cysteine and glycine rich protein 1); CSRP2 (cysteine and glycine rich protein 2); and CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See LRG1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (22823..25876)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ady3p Neighboring gene guanine deaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains. Müller L, et al. Nucleic Acids Res, 1994 Aug 11. PMID 8065929, Free PMC Article
  2. Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase. Duy DL, et al. PLoS One, 2017. PMID 28231297, Free PMC Article
  3. Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Stewart MS, et al. Eukaryot Cell, 2007 Feb. PMID 17172436, Free PMC Article
  4. Correcting an instance of synthetic lethality with a pro-survival sequence. Zhou DR, et al. Biochim Biophys Acta Mol Cell Res, 2020 Sep. PMID 32389645
  5. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie O, et al. FEBS Lett, 2001 Oct 5. PMID 11591390

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytogamy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTPase-activating protein LRG1
NP_010041.2
  • GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    22823..25876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180300.2 → NP_010041.2  TPA: GTPase-activating protein LRG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010041.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRB6, P35688, Q07735
    UniProtKB/TrEMBL
    A6ZX94, C7GJQ9, C8Z6N2, N1P766
    Conserved Domains (4) summary
    cd09391
    Location:28 → 90
    LIM1_Lrg1p_like; The first LIM domain of Lrg1p, a LIM and RhoGap domain containing protein
    cd09393
    Location:419 → 475
    LIM3_Lrg1p_like; The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein
    cd04397
    Location:728 → 959
    RhoGAP_fLRG1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1, ...
    cd08368
    Location:98 → 149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35688.3

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