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PCL9 Pcl9p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851375, updated on 4-Jan-2025

Summary

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Official Symbol
PCL9
Official Full Name
Pcl9p
Primary source
SGD:S000002338
Locus tag
YDL179W
See related
AllianceGenome:SGD:S000002338; FungiDB:YDL179W; VEuPathDB:YDL179W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in G1/S transition of mitotic cell cycle; regulation of establishment or maintenance of cell polarity; and regulation of transcription by RNA polymerase II. Located in cellular bud neck and incipient cellular bud site. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PCL9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (138291..139205)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATPase inhibitor Neighboring gene Ait1p Neighboring gene D-lactate dehydrogenase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae. Tennyson CN, et al. Mol Microbiol, 1998 Apr. PMID 9593297
  2. Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton. Lee J, et al. Curr Biol, 1998 Dec 3. PMID 9843683
  3. Swi5 controls a novel wave of cyclin synthesis in late mitosis. Aerne BL, et al. Mol Biol Cell, 1998 Apr. PMID 9529390, Free PMC Article
  4. Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. Sopko R, et al. EMBO J, 2007 Oct 31. PMID 17853895, Free PMC Article
  5. The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. Wang Z, et al. FEBS Lett, 2001 Oct 12. PMID 11602261

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment or maintenance of cell polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pcl9p
NP_010102.1
  • Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    138291..139205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180239.1 → NP_010102.1  TPA: Pcl9p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRH3, Q12477
    UniProtKB/TrEMBL
    B3LH63, B5VF93, C8Z6C5, G2WBY6, N1P5J3
    Conserved Domains (1) summary
    cd20557
    Location:48 → 143
    CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12477.1

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