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UGA3 Uga3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851384, updated on 4-Jan-2025

Summary

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Official Symbol
UGA3
Official Full Name
Uga3p
Primary source
SGD:S000002329
Locus tag
YDL170W
See related
AllianceGenome:SGD:S000002329; FungiDB:YDL170W; VEuPathDB:YDL170W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Involved in gamma-aminobutyric acid catabolic process; nitrogen utilization; and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See UGA3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (156318..157904)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Par32p Neighboring gene glutamate synthase (NADH) Neighboring gene Ugx2p Neighboring gene bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. André B. Mol Gen Genet, 1990 Jan. PMID 2109179
  2. The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae. Ishida C, et al. Mol Microbiol, 2006 Mar. PMID 16553884
  3. Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. Yoshida R, et al. Aging Cell, 2010 Aug. PMID 20550517
  4. Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. Idicula AM, et al. J Biol Chem, 2002 Nov 29. PMID 12235130, Free PMC Article
  5. Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Ramos F, et al. Eur J Biochem, 1985 Jun 3. PMID 3888627

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
    Title: Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
  2. Uga3 and Dal81 transcription factors depend on GABA to interact with UGA genes. Dal81 is necessary for Uga3 binding to UGA promoters. Uga3 factor acts as a bridge between Dal81 and DNA.
    Title: Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters.
  3. Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of gamma-aminobutyrate responsive genes.
    Title: Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes.
  4. Chromatin organization plays a major role in the bidirectional properties of the UGA3-GLT1 promoter, through the action of an upstream Abf1p-binding consensus sequence and a polydAdT(tract).
    Title: The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Uga3p
NP_010111.1
  • Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    156318..157904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180230.1 → NP_010111.1  TPA: Uga3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRI1, P26370
    UniProtKB/TrEMBL
    G2WBZ4, N1P923
    Conserved Domains (2) summary
    pfam00172
    Location:15 → 46
    Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
    pfam11951
    Location:121 → 528
    Fungal_trans_2; Fungal specific transcription factor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26370.1

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