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CLB3 B-type cyclin CLB3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851400, updated on 9-Dec-2024

Summary

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Official Symbol
CLB3
Official Full Name
B-type cyclin CLB3
Primary source
SGD:S000002314
Locus tag
YDL155W
See related
AllianceGenome:SGD:S000002314; FungiDB:YDL155W; VEuPathDB:YDL155W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G2/M transition of mitotic cell cycle; meiosis II; and regulation of cell cycle process. Located in cytoplasm; lipid droplet; and nucleus. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1) and CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CLB3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (176773..178056)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dmo2p Neighboring gene Cmr1p Neighboring gene MutS family protein MSH5 Neighboring gene rRNA-processing protein SAS10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel and highly divergent Arabidopsis cyclin isolated by complementation in budding yeast. Abrahams S, et al. Biochim Biophys Acta, 2001 May 28. PMID 11389963
  2. Isolation and characterisation of a mutation in the PMR1 gene encoding a Golgi membrane ATPase, which causes hypersensitivity to over-expression of Clb3 in Saccharomyces cerevisiae. Funakoshi M, et al. Mol Gen Genet, 2000 Sep. PMID 11016830
  3. TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast. Zachariae W, et al. Mol Biol Cell, 1996 May. PMID 8744951, Free PMC Article
  4. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz LE, et al. Cell, 2015 Oct 8. PMID 26411291, Free PMC Article
  5. Identification and characterization of individual cyclin-dependent kinase complexes from Saccharomyces cerevisiae. Shellman YG, et al. Yeast, 1999 Mar 15. PMID 10206189

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulated mitotic proteolysis of Clb3 is specifically required to make passage of Start in the succeeding cell cycle.
    Title: Degradation of the Mitotic Cyclin Clb3 Is not Required for Mitotic Exit but Is Necessary for G1 Cyclin Control of the Succeeding Cell Cycle.
  2. Deletion of CLB1 or CLB3 allows cdc14-arrested cells to complete cytokinesis, but not cell separation
    Title: Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
  3. SIC1-0P (all nine phosphorylation sites mutated) was lethal when combined with deletion of CLB2, CLB3, or CLB5; failure of Sic1 phosphorylation and proteolysis imposes a variable cell cycle delay and extreme sensitivity to B-type cyclin dosage
    Title: Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiosis II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic spindle pole body separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B-type cyclin CLB3
NP_010126.1
  • B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    176773..178056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180215.1 → NP_010126.1  TPA: B-type cyclin CLB3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRJ5, P24870
    UniProtKB/TrEMBL
    A6ZXH4, B3LH42, C8Z6E9, G2WC08, N1P7U2
    Conserved Domains (1) summary
    COG5024
    Location:4 → 421
    COG5024; Cyclin [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24870.3

Gene LinkOut

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