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LDB17 Ldb17p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851409, updated on 4-Jan-2025

Summary

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Official Symbol
LDB17
Official Full Name
Ldb17p
Primary source
SGD:S000002305
Locus tag
YDL146W
See related
AllianceGenome:SGD:S000002305; FungiDB:YDL146W; VEuPathDB:YDL146W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable Arp2/3 complex binding activity. Involved in endocytosis. Located in actin cortical patch. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See LDB17 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (192750..194225)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein NOP14 Neighboring gene proteasome regulatory particle lid subunit RPN5 Neighboring gene coatomer subunit alpha Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulators of yeast endocytosis identified by systematic quantitative analysis. Burston HE, et al. J Cell Biol, 2009 Jun 15. PMID 19506040, Free PMC Article
  2. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. Shen D, et al. J Cell Biol, 2013 Aug 5. PMID 23897890, Free PMC Article
  3. The fungicidal activity of amphotericin B requires autophagy-dependent targeting to the vacuole under a nutrient-starved condition in Saccharomyces cerevisiae. Yoshioka M, et al. Microbiology (Reading), 2016 May. PMID 26940206
  4. Identification of aluminium transport-related genes via genome-wide phenotypic screening of Saccharomyces cerevisiae. Tun NM, et al. Metallomics, 2014 Aug. PMID 24926745
  5. A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Tong AH, et al. Science, 2002 Jan 11. PMID 11743162

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud HDA PubMed 
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ldb17p
NP_010135.1
  • Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    192750..194225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180206.1 → NP_010135.1  TPA: Ldb17p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRK2, Q12342
    UniProtKB/TrEMBL
    A6ZXI1, N1P7M4
    Conserved Domains (1) summary
    pfam09431
    Location:235 → 372
    DUF2013; Protein of unknown function (DUF2013)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12342.1

Gene LinkOut

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