COP1 coatomer subunit alpha [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COP1
Official Full Name: coatomer subunit alpha
Primary source: SGD:S000002304
Locus tag: YDL145C
See related: AllianceGenome:SGD:S000002304; FungiDB:YDL145C; VEuPathDB:YDL145C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RET1; SEC33; SOO1
Summary: Enables ubiquitin binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; intracellular mRNA localization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See COP1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (194571..198176, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that ubiquitination, a modification well known to target membrane proteins to the lysosome or vacuole for degradation, can also function as recycling signal to sort a SNARE into COPI vesicles in a non-degradative pathway.
Title: COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.
These findings suggest that cisternal maturation involves a COPI-dependent pathway that recycles early Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins.
Title: COPI selectively drives maturation of the early Golgi.
analysis of the structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat
Title: Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat.
COPI in these mutants is released from Golgi membranes by brefeldin A, a drug that binds directly to guanine nucleotide exchange factor for ADP-ribosylation factor ribosylation factors and blocks Arf1 activation
Title: Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPI vesicle coat	IEA Inferred from Electronic Annotation more info
part_of COPI vesicle coat	IMP Inferred from Mutant Phenotype more info	PubMed
located_in COPI-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coatomer subunit alpha

NP_010136.1

Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

194571..198176 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180205.1 → NP_010136.1 TPA: coatomer subunit alpha [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010136.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRK3, P53622, Q07595

UniProtKB/TrEMBL

C7GKZ6

Conserved Domains (4) summary

cd00200
Location:17 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:59 → 93

7WD40; WD40 repeat [structural motif]

pfam04053
Location:343 → 770

Coatomer_WDAD; Coatomer WD associated region

pfam06957
Location:829 → 1199

COPI_C; Coatomer (COPI) alpha subunit C-terminus