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MRK1 putative serine/threonine protein kinase MRK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851480, updated on 4-Jan-2025

Summary

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Official Symbol
MRK1
Official Full Name
putative serine/threonine protein kinase MRK1
Primary source
SGD:S000002237
Locus tag
YDL079C
See related
AllianceGenome:SGD:S000002237; FungiDB:YDL079C; VEuPathDB:YDL079C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in regulation of protein catabolic process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MRK1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (312951..314748, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein P1A Neighboring gene branched-chain-2-oxoacid decarboxylase THI3 Neighboring gene malate dehydrogenase MDH3 Neighboring gene Vam6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy. Hardy TA, et al. Biochem Biophys Res Commun, 1995 Mar 17. PMID 7695629
  2. Glycogen synthase kinase-3 is involved in regulation of ribosome biogenesis in yeast. Yabuki Y, et al. Biosci Biotechnol Biochem, 2014. PMID 25035982
  3. Developmentally regulated internal transcription initiation during meiosis in budding yeast. Zhou S, et al. PLoS One, 2017. PMID 29136644, Free PMC Article
  4. The Saccharomyces cerevisiae GSK-3 beta homologs. Kassir Y, et al. Curr Drug Targets, 2006 Nov. PMID 17100585
  5. Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes. Hirata Y, et al. Mol Biol Cell, 2003 Jan. PMID 12529445, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative serine/threonine protein kinase MRK1
NP_010204.1
  • Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    312951..314748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180138.1 → NP_010204.1  TPA: putative serine/threonine protein kinase MRK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRS0, P50873, Q07470
    UniProtKB/TrEMBL
    C8Z4J1, N1PA98
    Conserved Domains (1) summary
    cd14137
    Location:159 → 449
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50873.2

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