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AHK1 Ahk1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851486, updated on 9-Dec-2024

Summary

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Official Symbol
AHK1
Official Full Name
Ahk1p
Primary source
SGD:S000002231
Locus tag
YDL073W
See related
AllianceGenome:SGD:S000002231; FungiDB:YDL073W; VEuPathDB:YDL073W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables MAP-kinase scaffold activity. Involved in negative regulation of protein phosphorylation and osmosensory signaling pathway via Sho1 osmosensor. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AHK1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (326613..329567)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase BRE1 Neighboring gene Yet3p Neighboring gene Bdf2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. Nishimura A, et al. Mol Cell Biol, 2016 Jan 19. PMID 26787842, Free PMC Article
  2. Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. Eisenberg-Bord M, et al. J Cell Biol, 2021 Nov 1. PMID 34694322, Free PMC Article
  3. Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Zou J, et al. Mol Biol Cell, 2009 Jul. PMID 19458192, Free PMC Article
  4. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. Kim JH, et al. J Biol Chem, 2009 Apr 17. PMID 19233841, Free PMC Article
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ahk1 is a scaffold protein in the HKR1 subbranch and prevents incorrect signal flow from Hkr1 to Kss1
    Title: Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway via Sho1 osmosensor IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Ahk1p
NP_010210.1
  • Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    326613..329567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180132.1 → NP_010210.1  TPA: Ahk1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010210.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRS6, Q07454
    UniProtKB/TrEMBL
    A6ZXQ5, N1P7Q7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07454.1

Gene LinkOut

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