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MTF2 Mtf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851517, updated on 4-Jan-2025

Summary

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Official Symbol
MTF2
Official Full Name
Mtf2p
Primary source
SGD:S000002202
Locus tag
YDL044C
See related
AllianceGenome:SGD:S000002202; FungiDB:YDL044C; VEuPathDB:YDL044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAM1
Summary
Enables RNA binding activity. Involved in mRNA processing and mitochondrial translation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MTF2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (373967..375289, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein YmS-T Neighboring gene FMN adenylyltransferase Neighboring gene Prp11p Neighboring gene NAD-dependent histone deacetylase SIR2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Change of serine309 into proline causes temperature sensitivity of the nuclear NAM1/MTF2 gene product for yeast mitochondria. Lisowsky T, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2124681, Free PMC Article
  2. Molecular analysis of the mitochondrial transcription factor mtf2 of Saccharomyces cerevisiae. Lisowsky T. Mol Gen Genet, 1990 Jan. PMID 2183001
  3. The NAM1 protein (NAM1p), which is selectively required for cox1, cytb and atp6 transcript processing/stabilisation, is located in the yeast mitochondrial matrix. Wallis MG, et al. Eur J Biochem, 1994 May 15. PMID 8200349
  4. The NAM1/MTF2 nuclear gene product is selectively required for the stability and/or processing of mitochondrial transcripts of the atp6 and of the mosaic, cox1 and cytb genes in Saccharomyces cerevisiae. Groudinsky O, et al. Mol Gen Genet, 1993 Sep. PMID 8413192
  5. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. Rodeheffer MS, et al. J Biol Chem, 2001 Mar 16. PMID 11118450, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mtf2p
NP_010240.1
  • Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    373967..375289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180103.1 → NP_010240.1  TPA: Mtf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRV2, P10849, Q05430
    UniProtKB/TrEMBL
    B3LGU2, C7GPW3, C8Z4M6, N1P641
    Conserved Domains (1) summary
    pfam19189
    Location:211 → 434
    Mtf2; Mtf2 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10849.1

Gene LinkOut

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