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SNQ2 ATP-binding cassette transporter SNQ2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851574, updated on 4-Jan-2025

Summary

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Official Symbol
SNQ2
Official Full Name
ATP-binding cassette transporter SNQ2
Primary source
SGD:S000002418
Locus tag
YDR011W
See related
AllianceGenome:SGD:S000002418; FungiDB:YDR011W; VEuPathDB:YDR011W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ABC-type xenobiotic transporter activity. Involved in intracellular monoatomic cation homeostasis. Located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SNQ2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (465919..470424)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene transcriptional regulator GAL3 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene DNA replication protein PSF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Servos J, et al. Mol Gen Genet, 1993 Jan. PMID 8437567
  2. Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. van Leeuwen JS, et al. Toxicol In Vitro, 2012 Mar. PMID 22138569
  3. Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p. Hendrych T, et al. Biochim Biophys Acta, 2009 Mar. PMID 19111673
  4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707993
  5. Impact of the growth phase on the activity of multidrug resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source. Cadek R, et al. Biochim Biophys Acta, 2004 Oct 11. PMID 15471577

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae.
    Title: Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae.
  2. Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.Caffeine was exported by Snq2p and Pdr5p.
    Title: Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.
  3. The multidrug resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers of biofilms.
    Title: Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies.
  4. Pdr5p and Snq2p transporters play important physiological roles and significantly influence the developmental phases and physiology of yeast populations growing in a liquid culture.
    Title: Putative role for ABC multidrug exporters in yeast quorum sensing.
  5. activity of Snq2 in a strain with wild-type PDR1 allele was shown to drop sharply on glucose depletion from the medium and then again at the end of the diauxic shift when the cells are adapted to growth on respiratory substrates.
    Title: Impact of the growth phase on the activity of multidrug resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular monoatomic cation homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette transporter SNQ2
NP_010294.1
  • Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    465919..470424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180319.1 → NP_010294.1  TPA: ATP-binding cassette transporter SNQ2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010294.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRZ7, P32568
    UniProtKB/TrEMBL
    C8Z4T0, N1P6B2
    Conserved Domains (1) summary
    TIGR00956
    Location:103 → 1480
    3a01205; Pleiotropic Drug Resistance (PDR) Family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32568.2

Gene LinkOut

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