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ATG31 Atg31p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851585, updated on 4-Jan-2025

Summary

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Official Symbol
ATG31
Official Full Name
Atg31p
Primary source
SGD:S000002429
Locus tag
YDR022C
See related
AllianceGenome:SGD:S000002429; FungiDB:YDR022C; VEuPathDB:YDR022C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CIS1
Summary
Involved in autophagy of mitochondrion and piecemeal microautophagy of the nucleus. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ATG31 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (488072..488662, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative uridine kinase DAS2 Neighboring gene ATP-dependent RNA helicase FAL1 Neighboring gene tRNA-Val Neighboring gene serine--tRNA ligase SES1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of Atg31 is required for autophagy. Feng W, et al. Protein Cell, 2015 Apr. PMID 25773276, Free PMC Article
  2. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2007 May 4. PMID 17362880
  3. Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19755117
  4. Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29. Chew LH, et al. Autophagy, 2013 Oct. PMID 23939028, Free PMC Article
  5. Scaffolding the cup-shaped double membrane in autophagy. Bahrami AH, et al. PLoS Comput Biol, 2017 Oct. PMID 29065154, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of Atg31 is required for autophagy.
    Title: Phosphorylation of Atg31 is required for autophagy.
  2. Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
    Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
  3. single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
    Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
  4. Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
    Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in karyogamy IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Atg31p
NP_010305.1
  • Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    488072..488662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180330.1 → NP_010305.1  TPA: Atg31p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010305.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS08, Q03939, Q12421
    UniProtKB/TrEMBL
    A6ZXY6, B3LGP2, C8Z4U2, N1P7Z6
    Conserved Domains (1) summary
    pfam09795
    Location:2 → 196
    Atg31; Autophagy-related protein 31
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12421.1

Gene LinkOut

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