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ENA2 Na(+)-exporting P-type ATPase ENA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851609, updated on 9-Dec-2024

Summary

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Official Symbol
ENA2
Official Full Name
Na(+)-exporting P-type ATPase ENA2
Primary source
SGD:S000002446
Locus tag
YDR039C
See related
AllianceGenome:SGD:S000002446; FungiDB:YDR039C; VEuPathDB:YDR039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables P-type potassium transmembrane transporter activity and P-type sodium transporter activity. Involved in potassium ion transport; sodium ion transport; and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ENA2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (531307..534582, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase KRS1 Neighboring gene putative Na(+)-exporting P-type ATPase ENA5 Neighboring gene Na(+)/Li(+)-exporting P-type ATPase ENA1 Neighboring gene mitochondrial 37S ribosomal protein RSM10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide overexpression screen for sodium acetate resistance in Saccharomyces cerevisiae. Peña PV, et al. J Biotechnol, 2013 Mar 10. PMID 23262128
  2. A novel P-type ATPase from yeast involved in sodium transport. Haro R, et al. FEBS Lett, 1991 Oct 21. PMID 1657642
  3. Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Garciadeblas B, et al. Mol Gen Genet, 1993 Jan. PMID 8437581
  4. In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2. Leak FW Jr, et al. DNA Cell Biol, 1999 Feb. PMID 10073572
  5. Role of the glutamic and aspartic residues in Na+-ATPase function in the ZrENA1 gene of Zygosaccharomyces rouxii. Watanabe Y, et al. FEMS Microbiol Lett, 2002 Mar 19. PMID 12007651

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ABC-type sodium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables P-type potassium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type potassium transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables P-type sodium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type sodium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type sodium transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Na(+)-exporting P-type ATPase ENA2
NP_010324.3
  • P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    531307..534582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180347.3 → NP_010324.3  TPA: Na(+)-exporting P-type ATPase ENA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010324.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS27, Q01896
    UniProtKB/TrEMBL
    C8Z4W0
    Conserved Domains (1) summary
    TIGR01523
    Location:11 → 1055
    ATPase-IID_K-Na; potassium and/or sodium efflux P-type ATPase, fungal-type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01896.1

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