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AIM7 Aim7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851635, updated on 9-Dec-2024

Summary

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Official Symbol
AIM7
Official Full Name
Aim7p
Primary source
SGD:S000002470
Locus tag
YDR063W
See related
AllianceGenome:SGD:S000002470; FungiDB:YDR063W; VEuPathDB:YDR063W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GMF1
Summary
Predicted to enable Arp2/3 complex binding activity. Involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AIM7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (578663..579112)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2 Neighboring gene ribosomal 40S subunit protein S13 Neighboring gene Rrg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Gandhi M, et al. Curr Biol, 2010 May 11. PMID 20362448, Free PMC Article
  2. Combinatorial genetic analysis of a network of actin disassembly-promoting factors. Ydenberg CA, et al. Cytoskeleton (Hoboken), 2015 Jul. PMID 26147656, Free PMC Article
  3. GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton. Nakano K, et al. Cytoskeleton (Hoboken), 2010 Jun. PMID 20517925
  4. GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. Ydenberg CA, et al. Curr Biol, 2013 Jun 17. PMID 23727094, Free PMC Article
  5. Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF. Guo S, et al. Nat Commun, 2018 Jul 24. PMID 30042427, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament debranching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament debranching IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aim7p
NP_010348.1
  • Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    578663..579112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180371.1 → NP_010348.1  TPA: Aim7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS49, Q12156
    UniProtKB/TrEMBL
    A6ZY28, B3LGK7, C8Z4Y2, G2WAG7, N1P4L3
    Conserved Domains (1) summary
    cl15697
    Location:7 → 136
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12156.1

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