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FIN1 Fin1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851708, updated on 4-Jan-2025

Summary

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Official Symbol
FIN1
Official Full Name
Fin1p
Primary source
SGD:S000002537
Locus tag
YDR130C
See related
AllianceGenome:SGD:S000002537; FungiDB:YDR130C; VEuPathDB:YDR130C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables microtubule binding activity. A structural constituent of cytoskeleton. Involved in several processes, including cytoskeleton organization; deactivation of mitotic spindle assembly checkpoint; and protein localization to kinetochore. Located in cytoskeleton; kinetochore; and nucleus. Part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See FIN1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (715747..716622, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mtc5p Neighboring gene fimbrin Neighboring gene uncharacterized protein Neighboring gene Mrx16p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies. van Hemert MJ, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11929974, Free PMC Article
  2. The role of self-association in Fin1 function on the mitotic spindle. Woodbury EL, et al. J Biol Chem, 2007 Nov 2. PMID 17804403
  3. A general strategy for studying multisite protein phosphorylation using label-free selected reaction monitoring mass spectrometry. Eissler CL, et al. Anal Biochem, 2011 Nov 15. PMID 21810403, Free PMC Article
  4. Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast. van Hemert MJ, et al. J Biol Chem, 2003 Apr 25. PMID 12551942
  5. Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase. Bokros M, et al. PLoS Genet, 2021 May. PMID 34033659, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
    Title: Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
  2. Our results suggest the stoichiometry of outer kinetochore submodules is strongly influenced by factors at the kinetochore-microtubule interface such as Fin1 and Dam1, and phosphorylation by cyclin-dependent kinase.
    Title: The stoichiometry of the outer kinetochore is modulated by microtubule-proximal regulatory factors.
  3. used quantitative proteomics to identify the Fin1 protein as a PP1 regulatory subunit
    Title: Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.
  4. Findings suggest that the N-terminal region of Fin1 is sufficient for its regulated function as a spindle-stabilizing factor and that this function involves association with the spindle pole body.
    Title: The role of self-association in Fin1 function on the mitotic spindle.
  5. we identify the budding-yeast protein Fin1 as a spindle-stabilizing protein whose activity is strictly limited to anaphase by changes in its phosphorylation state and rate of degradation.
    Title: Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in deactivation of mitotic spindle assembly checkpoint IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in deactivation of mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intermediate filament cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body HDA PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fin1p
NP_010415.1
  • Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    715747..716622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180438.1 → NP_010415.1  TPA: Fin1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010415.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSB6, Q03898
    UniProtKB/TrEMBL
    B5VG28, C7GIN8, C8Z546
    Conserved Domains (1) summary
    pfam17300
    Location:15 → 283
    FIN1; Filament protein FIN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03898.1

Gene LinkOut

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