CTH1 putative mRNA-binding protein CTH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CTH1
Official Full Name: putative mRNA-binding protein CTH1
Primary source: SGD:S000002558
Locus tag: YDR151C
See related: AllianceGenome:SGD:S000002558; FungiDB:YDR151C; VEuPathDB:YDR151C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable mRNA binding activity. Involved in intracellular iron ion homeostasis and nuclear-transcribed mRNA catabolic process. Predicted to be located in nucleus. Orthologous to several human genes including ZFP36 (ZFP36 ring finger protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CTH1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (764178..765155, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Negative feedback regulation of the CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.
Title: Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.
metabolic reprogramming as a consequence of Fe starvation that is dependent on the coordinated activities of CTH1 and CTH2
Title: Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: putative mRNA-binding protein CTH1

NP_010435.1

mRNA binding protein, member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; functions with Tis11p in regulation of iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

764178..765155 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180458.1 → NP_010435.1 TPA: putative mRNA-binding protein CTH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010435.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSD3, P47976

UniProtKB/TrEMBL

A6ZYB1, B3LGD1, C7GX33, C8Z566, G2WAQ1, N1PAE3

Conserved Domains (1) summary

COG5063
Location:1 → 323

CTH1; CCCH-type Zn-finger protein [General function prediction only]