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SSY1 Ssy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851738, updated on 4-Jan-2025

Summary

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Official Symbol
SSY1
Official Full Name
Ssy1p
Primary source
SGD:S000002567
Locus tag
YDR160W
See related
AllianceGenome:SGD:S000002567; FungiDB:YDR160W; VEuPathDB:YDR160W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RAA1; SHR10
Summary
Predicted to enable amino acid transmembrane transporter activity. Involved in response to amino acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SSY1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (776163..778721)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Sac3p Neighboring gene Acl4p Neighboring gene Nbp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. Wu B, et al. J Cell Biol, 2006 May 8. PMID 16651382, Free PMC Article
  2. Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Brown KM, et al. Mol Ecol, 2008 Jun. PMID 18422925
  3. Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. McCusker JH, et al. Mol Cell Biol, 1990 Jun. PMID 2188104, Free PMC Article
  4. Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor. Poulsen P, et al. Mol Membr Biol, 2008 Feb. PMID 18307103
  5. Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions. Kralt A, et al. Traffic, 2015 Feb. PMID 25409870

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
    Title: Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
  2. The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
    Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
  3. C-terminal of Ssy1 carries a functional ER-export motif required for proper localization of Ssy1 to the plasma membrane. Ssy1 functions as the primary amino acid receptor and that it carries out this function at the PM.
    Title: Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of plasma membrane-endoplasmic reticulum junctions.
  4. Ssy1 localization depends on the presence of a PM-binding domain, an intrinsically disordered linker region of sufficient length.
    Title: Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions.
  5. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
    Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
  6. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
  7. SSY1 mutants that constitutively activate a target promoter, were isolated.
    Title: Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor.
  8. Data confirm that a frameshift mutation in a mononucleotide run of eight consecutive T's in the coding region SSY1 causes dramatic differences in gene-expression levels of key genes involved in amino acid biosynthesis.
    Title: Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.
  9. SSY1, a tranporter-like sensor, allows the cell to respond to changes in nutrient availability through detection of the relative concentrations of intra- and extracellular ligand.
    Title: Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amino acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ssy1p
NP_010444.1
  • Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    776163..778721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180467.1 → NP_010444.1  TPA: Ssy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010444.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSE0, Q03770
    UniProtKB/TrEMBL
    B3LGC4, C7GX40
    Conserved Domains (1) summary
    TIGR00913
    Location:278 → 819
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03770.1

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