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NVJ3 Nvj3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851760, updated on 4-Jan-2025

Summary

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Official Symbol
NVJ3
Official Full Name
Nvj3p
Primary source
SGD:S000002587
Locus tag
YDR179W-A
See related
AllianceGenome:SGD:S000002587; FungiDB:YDR179W-A; VEuPathDB:YDR179W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in vacuole-ER tethering. Located in nucleus-vacuole junction. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NVJ3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (819433..820824)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase membrane anchor subunit SDH4 Neighboring gene Csn9p Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene Sas4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. Henne WM, et al. J Cell Biol, 2015 Aug 17. PMID 26283797, Free PMC Article
  2. Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation. Sharmin T, et al. Biochem Biophys Res Commun, 2021 May 7. PMID 33740659
  3. The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ. Tasnin MN, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33706099
  4. Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress. Hariri H, et al. EMBO Rep, 2018 Jan. PMID 29146766, Free PMC Article
  5. Membrane contact sites regulate vacuolar fission via sphingolipid metabolism. Hanaoka K, et al. Elife, 2024 Mar 27. PMID 38536872, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in vacuole-ER tethering ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus-vacuole junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nvj3p
NP_010465.4
  • Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    819433..820824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180487.3 → NP_010465.4  TPA: Nvj3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010465.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSG2, Q03983, Q03984
    UniProtKB/TrEMBL
    G2WAS8
    Conserved Domains (1) summary
    pfam02194
    Location:98 → 246
    PXA; PXA domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03983.2

Gene LinkOut

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