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TLD1 triglyceride-associated lipolysis regulator TLD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851868, updated on 9-Dec-2024

Summary

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Official Symbol
TLD1
Official Full Name
triglyceride-associated lipolysis regulator TLD1
Primary source
SGD:S000002683
Locus tag
YDR275W
See related
AllianceGenome:SGD:S000002683; FungiDB:YDR275W; VEuPathDB:YDR275W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BSC2
Summary
Acts upstream of or within cellular lipid catabolic process. Is active in lipid droplet. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TLD1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1012252..1012959)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Don1p Neighboring gene uncharacterized protein Neighboring gene Pmp3p Neighboring gene Mth1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae. Kong Y, et al. Free Radic Res, 2020 Apr. PMID 32295440
  2. A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae. Samanfar B, et al. Mol Biosyst, 2014 Apr. PMID 24535059
  3. Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation. Speer NO, et al. J Cell Biol, 2024 Jan 1. PMID 37889293, Free PMC Article
  4. Identification of stop codon readthrough genes in Saccharomyces cerevisiae. Namy O, et al. Nucleic Acids Res, 2003 May 1. PMID 12711673, Free PMC Article
  5. Genome-wide analysis of mRNAs targeted to yeast mitochondria. Marc P, et al. EMBO Rep, 2002 Feb. PMID 11818335, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae.
    Title: BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae.
  2. BSC2 deletion increased the rate of premature stop codon bypass. Bsc2p may function in negative regulation of premature stop codon bypass and hence regulate its own expression.
    Title: A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in lipid droplet HDA PubMed 
is_active_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
triglyceride-associated lipolysis regulator TLD1
NP_010561.1
  • Protein that regulates lipolysis; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; TLD1 has a paralog, IRC23, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1012252..1012959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180583.1 → NP_010561.1  TPA: triglyceride-associated lipolysis regulator TLD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010561.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSQ6, Q05611
    UniProtKB/TrEMBL
    A6ZYM5, B3LG18, B5VGF6, C7GS93, C8Z5I8, G2WB15, N1PAG8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05611.1

Gene LinkOut

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