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HDA2 Hda2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851889, updated on 9-Dec-2024

Summary

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Official Symbol
HDA2
Official Full Name
Hda2p
Primary source
SGD:S000002703
Locus tag
YDR295C
See related
AllianceGenome:SGD:S000002703; FungiDB:YDR295C; VEuPathDB:YDR295C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PLO2
Summary
Enables DNA binding activity and chromatin binding activity. Contributes to histone deacetylase activity. Involved in negative regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated gene silencing. Located in cytosol and nucleus. Part of HDA1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HDA2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1052623..1054647, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA-binding translational repressor SSD1 Neighboring gene sphinganine-1-phosphate aldolase DPL1 Neighboring gene mitochondrial 54S ribosomal protein MHR1 Neighboring gene sphingosine hydroxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. Lee JH, et al. J Mol Biol, 2009 Aug 28. PMID 19573535
  2. Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Lee JH, et al. Sci Adv, 2021 Jan. PMID 33523989, Free PMC Article
  3. Lysine acetylation regulates the activity of nuclear Pif1. Ononye OE, et al. J Biol Chem, 2020 Nov 13. PMID 32878983, Free PMC Article
  4. HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Wu J, et al. Proc Natl Acad Sci U S A, 2001 Apr 10. PMID 11287668, Free PMC Article
  5. Deletion of host histone acetyltransferases and deacetylases strongly affects Agrobacterium-mediated transformation of Saccharomyces cerevisiae. Soltani J, et al. FEMS Microbiol Lett, 2009 Sep. PMID 19659745

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulatory ncRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HDA1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HDA1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of HDA1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hda2p
NP_010581.3
  • Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1052623..1054647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180603.3 → NP_010581.3  TPA: Hda2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010581.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSS4, Q06629
    UniProtKB/TrEMBL
    G2WB33, N1P565
    Conserved Domains (2) summary
    TIGR00618
    Location:445 → 641
    sbcc; exonuclease SbcC
    pfam11496
    Location:11 → 319
    HDA2-3; Class II histone deacetylase complex subunits 2 and 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06629.1

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