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MCM21 Mcm21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851916, updated on 4-Jan-2025

Summary

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Official Symbol
MCM21
Official Full Name
Mcm21p
Primary source
SGD:S000002726
Locus tag
YDR318W
See related
AllianceGenome:SGD:S000002726; FungiDB:YDR318W; VEuPathDB:YDR318W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CTF5
Summary
Involved in establishment of mitotic sister chromatid cohesion; negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination; and protein localization to chromosome, centromeric region. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MCM21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (1103758..1104947)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Him1p Neighboring gene Yft2p Neighboring gene auxilin-like protein SWA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission. Poddar A, et al. Mol Microbiol, 1999 Jan. PMID 9987135
  2. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
  3. A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. Tsabar M, et al. PLoS Genet, 2016 Apr. PMID 27128635, Free PMC Article
  4. Geometric partitioning of cohesin and condensin is a consequence of chromatin loops. Lawrimore J, et al. Mol Biol Cell, 2018 Nov 1. PMID 30207827, Free PMC Article
  5. Synthetic dosage lethality. Measday V, et al. Methods Enzymol, 2002. PMID 12073321

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centromere complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COMA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mcm21p
NP_010604.4
  • Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1103758..1104947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180626.3 → NP_010604.4  TPA: Mcm21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010604.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSU9, Q06675
    UniProtKB/TrEMBL
    A6ZYR9, B3LFY0, C7GWL5, C8Z5M9, G2WB56, N1P756
    Conserved Domains (1) summary
    pfam09496
    Location:175 → 313
    CENP-O; Cenp-O kinetochore centromere component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06675.2

Gene LinkOut

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