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UTP4 Utp4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851924, updated on 9-Dec-2024

Summary

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Official Symbol
UTP4
Official Full Name
Utp4p
Primary source
SGD:S000002732
Locus tag
YDR324C
See related
AllianceGenome:SGD:S000002732; FungiDB:YDR324C; VEuPathDB:YDR324C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Located in nucleolus. Part of small-subunit processome and t-UTP complex. Used to study liver cirrhosis. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See UTP4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1114433..1116763, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit e Neighboring gene phosphatidylinositol-3-phosphate binding protein Neighboring gene condensin subunit YCG1 Neighboring gene Ysp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes. Segerstolpe A, et al. Nucleic Acids Res, 2008 Aug. PMID 18586827, Free PMC Article
  2. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Braun CM, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31745560, Free PMC Article
  3. The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Freed EF, et al. Nucleic Acids Res, 2010 Aug. PMID 20385600, Free PMC Article
  4. The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. Léger-Silvestre I, et al. EMBO J, 2004 Jun 16. PMID 15167894, Free PMC Article
  5. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Schilling V, et al. Yeast, 2012 May. PMID 22588997

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of 90S preribosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of t-UTP complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Utp4p
NP_010611.3
  • Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1114433..1116763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180632.3 → NP_010611.3  TPA: Utp4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010611.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSV7, Q06679
    UniProtKB/TrEMBL
    A6ZYS7, B3LFX2, C7GWM3, C8Z5N7, G2WB64, N1P595
    Conserved Domains (2) summary
    sd00039
    Location:58 → 94
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:53 → 304
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06679.1

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