U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RQC1 Rqc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851933, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
RQC1
Official Full Name
Rqc1p
Primary source
SGD:S000002741
Locus tag
YDR333C
See related
AllianceGenome:SGD:S000002741; FungiDB:YDR333C; VEuPathDB:YDR333C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Involved in rescue of stalled ribosome and ribosome-associated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of RQC complex. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RQC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1133260..1135431, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase Neighboring gene double-stranded DNA-dependent ATPase Neighboring gene chromatin-remodeling protein SWR1 Neighboring gene karyopherin MSN5

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Osuna BA, et al. Elife, 2017 Jul 18. PMID 28718767, Free PMC Article
  2. Failure of RQC machinery causes protein aggregation and proteotoxic stress. Choe YJ, et al. Nature, 2016 Mar 10. PMID 26934223
  3. Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. Yang J, et al. Elife, 2016 Apr 1. PMID 27033550, Free PMC Article
  4. Vms1p is a release factor for the ribosome-associated quality control complex. Zurita Rendón O, et al. Nat Commun, 2018 Jun 6. PMID 29875445, Free PMC Article
  5. Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1. Zheng J, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28864412

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex.
    Title: Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex.
  2. The authors determined that the Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elongation is mechanistically distinct from canonical translation, that Ltn1p-mediated ubiquitination depends on the poorly characterized Ribosome-associated Quality control Complex (RQC) component Rqc1p, and that the process of CAT tailing enables robust ubiquitination of the nascent polypeptide.
    Title: In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.
  3. Data show that Saccharomyces cerevisiae proteins Rqc1, Ltn1, and Cdc48 prevent the aggregation of aberrant proteins that can only appear after C-terminal alanine-threonine tail (CAT-tail) addition by Rqc2.
    Title: Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rescue of stalled ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RQC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RQC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rqc1p
NP_010620.3
  • Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1133260..1135431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180641.3 → NP_010620.3  TPA: Rqc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010620.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSW5, Q05468
    UniProtKB/TrEMBL
    A6ZYT5, B3LFW4, B5VGL6, C7GWN0, C8Z5P5, N1P6Y5
    Conserved Domains (1) summary
    pfam04910
    Location:327 → 663
    Tcf25; Transcriptional repressor TCF25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05468.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools