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SDH6 Sdh6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851986, updated on 4-Jan-2025

Summary

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Official Symbol
SDH6
Official Full Name
Sdh6p
Primary source
SGD:S000007605
Locus tag
YDR379C-A
See related
AllianceGenome:SGD:S000007605; FungiDB:YDR379C-A; VEuPathDB:YDR379C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrion. Used to study mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in mitochondrial complex II deficiency. Orthologous to human SDHAF1 (succinate dehydrogenase complex assembly factor 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SDH6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1233278..1233517, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit LSM6 Neighboring gene GTPase-activating protein RGA2 Neighboring gene phenylpyruvate decarboxylase ARO10 Neighboring gene RNA-binding protein YRA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Ghezzi D, et al. Nat Genet, 2009 Jun. PMID 19465911
  2. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, et al. Mol Cell, 2018 Aug 16. PMID 30118679, Free PMC Article
  3. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Na U, et al. Cell Metab, 2014 Aug 5. PMID 24954417, Free PMC Article
  4. Identification and characterization of genes related to the production of organic acids in yeast. Yoshida S, et al. J Biosci Bioeng, 2012 May. PMID 22277779
  5. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex II assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex II assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sdh6p
NP_076888.3
  • Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1233278..1233517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184471.3 → NP_076888.3  TPA: Sdh6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_076888.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZYX9, D6VT12, Q3E785
    UniProtKB/TrEMBL
    B3LFS2, C7GMF6, C8Z5U3, G2WBB7, N1P5F2
    Conserved Domains (1) summary
    cd20268
    Location:6 → 69
    Complex1_LYR_SDHAF1_LYRM8; LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E785.1

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