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UBA2 E1 ubiquitin-activating protein UBA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851998, updated on 4-Jan-2025

Summary

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Official Symbol
UBA2
Official Full Name
E1 ubiquitin-activating protein UBA2
Primary source
SGD:S000002798
Locus tag
YDR390C
See related
AllianceGenome:SGD:S000002798; FungiDB:YDR390C; VEuPathDB:YDR390C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UAL1
Summary
Contributes to SUMO activating enzyme activity. Involved in protein sumoylation. Located in nucleus. Part of SUMO activating enzyme complex. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See UBA2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1254937..1256847, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene amphiphysin Neighboring gene GTPase-activating protein SAC7 Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR assignments of ubiquitin fold domain (UFD) in SUMO-activating enzyme subunit 2 from rice. Suzuki R, et al. Biomol NMR Assign, 2011 Oct. PMID 21523438
  2. An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. Dohmen RJ, et al. J Biol Chem, 1995 Jul 28. PMID 7629121
  3. Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation. Bencsath KP, et al. J Biol Chem, 2002 Dec 6. PMID 12354763
  4. Purification of SUMO conjugating enzymes and kinetic analysis of substrate conjugation. Yunus AA, et al. Methods Mol Biol, 2009. PMID 19107417, Free PMC Article
  5. UBC9 autosumoylation negatively regulates sumoylation of septins in Saccharomyces cerevisiae. Ho CW, et al. J Biol Chem, 2011 Jun 17. PMID 21518767, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to SUMO activating enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E1 ubiquitin-activating protein UBA2
NP_010678.3
  • Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1254937..1256847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180698.3 → NP_010678.3  TPA: E1 ubiquitin-activating protein UBA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010678.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT24, P52488
    UniProtKB/TrEMBL
    B3LFR0, B5VGS0, C7GSD2, C8Z5V4, N1PAJ2
    Conserved Domains (3) summary
    cd01489
    Location:23 → 438
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam10585
    Location:183 → 370
    UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
    cl39046
    Location:453 → 518
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52488.1

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