UTP5 Utp5p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UTP5
Official Full Name: Utp5p
Primary source: SGD:S000002806
Locus tag: YDR398W
See related: AllianceGenome:SGD:S000002806; FungiDB:YDR398W; VEuPathDB:YDR398W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Located in nucleolus and rDNA heterochromatin. Part of small-subunit processome and t-UTP complex. Orthologous to human WDR43 (WD repeat domain 43). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See UTP5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1267471..1269402)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-32d1 (e-PCR)
- UniSTS:257597

px-36g2 (e-PCR)
- UniSTS:258388

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in rDNA heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IEA Inferred from Electronic Annotation more info
part_of t-UTP complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Utp5p

NP_010686.1

Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1267471..1269402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180706.1 → NP_010686.1 TPA: Utp5p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010686.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT31, Q04177

UniProtKB/TrEMBL

C8Z5W2, N1P753

Conserved Domains (3) summary

sd00039
Location:60 → 102

7WD40; WD40 repeat [structural motif]

pfam04003
Location:448 → 548

Utp12; Dip2/Utp12 Family

cl29593
Location:3 → 256

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...