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SIZ1 SUMO ligase SIZ1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852018, updated on 4-Jan-2025

Summary

Official Symbol
SIZ1
Official Full Name
SUMO ligase SIZ1
Primary source
SGD:S000002817
Locus tag
YDR409W
See related
AllianceGenome:SGD:S000002817; FungiDB:YDR409W; VEuPathDB:YDR409W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ULL1
Summary
Enables SUMO transferase activity and double-stranded DNA binding activity. Involved in several processes, including DNA double-strand break attachment to nuclear envelope; negative regulation of protein ubiquitination; and protein sumoylation. Located in chromatin and septin ring. Orthologous to several human genes including PIAS2 (protein inhibitor of activated STAT 2); PIAS3 (protein inhibitor of activated STAT 3); and PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See SIZ1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1289406..1292120)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Trs120p Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase Neighboring gene Dfm1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables SUMO transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break attachment to nuclear envelope IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein sumoylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in septin ring IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SUMO ligase SIZ1
NP_010697.3
  • SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1289406..1292120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180717.3NP_010697.3  TPA: SUMO ligase SIZ1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010697.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT41, Q04195, Q06762, Q7LIJ4
    UniProtKB/TrEMBL
    B5VGU1, N1P5I8
    Conserved Domains (3) summary
    smart00513
    Location:3468
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16793
    Location:358405
    SP-RING_ScSiz_like; SP-RING finger found in Saccharomyces cerevisiae E3 SUMO-protein ligase SIZ1, SIZ2, and similar proteins
    pfam14324
    Location:176311
    PINIT; PINIT domain