U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DFM1 Dfm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852020, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
DFM1
Official Full Name
Dfm1p
Primary source
SGD:S000002819
Locus tag
YDR411C
See related
AllianceGenome:SGD:S000002819; FungiDB:YDR411C; VEuPathDB:YDR411C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein folding chaperone. Involved in ERAD pathway; endoplasmic reticulum unfolded protein response; and regulation of retrograde protein transport, ER to cytosol. Is active in endoplasmic reticulum. Orthologous to several human genes including DERL1 (derlin 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DFM1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1293369..1294394, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene SUMO ligase SIZ1 Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase Neighboring gene Rrp17p Neighboring gene Erd1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Assays for studying normal versus suppressive ERAD-associated retrotranslocation pathways in yeast. Bhaduri S, et al. STAR Protoc, 2021 Sep 17. PMID 34278330, Free PMC Article
  2. Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. Hitt R, et al. FEMS Yeast Res, 2004 May. PMID 15093775
  3. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Sato BK, et al. Yeast, 2006 Oct-Nov. PMID 17083136
  4. The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation. Vitali DG, et al. J Cell Biol, 2024 May 6. PMID 38448163, Free PMC Article
  5. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Neal S, et al. Mol Cell, 2018 Jan 18. PMID 29351849, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation.
    Title: The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation.
  2. Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress.
    Title: Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress.
  3. Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.
    Title: Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.
  4. Results show Ypf1 is an Endoplasmic Reticulum-resident aspartyl intramembrane protease with a presenilin fold, and identified Doa10 and Dfm1 as its cofactors.
    Title: The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.
  5. Dfm1 was part of complexes which contain the ERAD-L ligase Hrd1/Der3 and Der1 as well as the ERAD-C ligase Doa10. Dfm1 forms a complex with the AAA-ATPase Cdc48 in a strain lacking the Cdc48 membrane-recruiting component Ubx2.
    Title: Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.
  6. Dfm1p degradation complex contains the Cdc48p cofactors Ubx1p and Ubx7p
    Title: The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p.
  7. Dfm1p interacts with Cdc48p through its SHP boxes, and so defines a new motif for interaction with this widely-employed AAA-ATPase.
    Title: Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Dfm1p
NP_010699.1
  • Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; acts as disaggregase that removes misfolded membrane protein aggregates; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1293369..1294394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180719.1 → NP_010699.1  TPA: Dfm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010699.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT43, Q12743, Q7LIJ5
    UniProtKB/TrEMBL
    B3LFP3, C7GY32, C8Z5X4, N1P7E8
    Conserved Domains (1) summary
    COG5291
    Location:9 → 341
    COG5291; Predicted membrane protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12743.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools