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SAM2 methionine adenosyltransferase SAM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852113, updated on 9-Dec-2024

Summary

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Official Symbol
SAM2
Official Full Name
methionine adenosyltransferase SAM2
Primary source
SGD:S000002910
Locus tag
YDR502C
See related
AllianceGenome:SGD:S000002910; FungiDB:YDR502C; VEuPathDB:YDR502C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ETH2
Summary
Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and methionine metabolic process. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to several human genes including MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SAM2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1453310..1454464, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L37B Neighboring gene Plm2p Neighboring gene phosphatidate phosphatase LPP1 Neighboring gene Spg3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. tRNAs undermethylation in a met-regulatory mutant of Saccharomyces cerevisiae. Fesneau C, et al. Biochimie, 1975. PMID 1096967
  2. Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae. Dato L, et al. Microb Cell Fact, 2014 Oct 30. PMID 25359316, Free PMC Article
  3. Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization. Luo Y, et al. Biotechnol Prog, 2008 Jan-Feb. PMID 18078345
  4. Biosynthesis of methionine and its control in wild type and regulatory mutants of Saccharomyces cerevisiae. Antoniewski J, et al. Biochimie, 1973 May. PMID 4585174
  5. S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases. Cherest H, et al. Mol Gen Genet, 1978 Jul 11. PMID 355845

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAM1 and SAM2 have different effects on genome stability through distinctive effects on gene expression and AdoMet levels.
    Title: Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.
  2. Data showed that co-expression of MET6 and SAM2 improved intracellular methionine availability and redirected the methionine to S-adenosyl-L-methionine biosynthesis.
    Title: Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae.
  3. modulation of SAM2 can have different outcomes, from clear effects to no significant phenotypic responses, upon lactic acid stress in different genetic backgrounds
    Title: Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae.
  4. SAM2 was successfully produced at high level by the recombinant methylotrophic yeast Pichia pastoris, and the secreted His6-tagged SAM synthetase was purified in a single chromatography step with a yield of approximately 82% for the total activity.
    Title: Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methionine adenosyltransferase SAM2
NP_010790.3
  • S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1453310..1454464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180810.3 → NP_010790.3  TPA: methionine adenosyltransferase SAM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010790.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTC4, E9P927, P19358
    UniProtKB/TrEMBL
    A6ZZ91, B3LFG5, B5VH29, C7GKT8, C8Z659, G2WBN0, N1P7G8, T2A536
    Conserved Domains (1) summary
    cd18079
    Location:8 → 380
    S-AdoMet_synt; S-adenosylmethionine synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19358.3

Gene LinkOut

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