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carbonyl reductase (NADPH-dependent) [ Saccharomyces cerevisiae S288C ]

Gene ID: 852154, updated on 9-Dec-2024

Summary

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Official Full Name
carbonyl reductase (NADPH-dependent)
Primary source
SGD:S000002949
Locus tag
YDR541C
See related
AllianceGenome:SGD:S000002949; FungiDB:YDR541C; VEuPathDB:YDR541C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldehyde dehydrogenase (NADP+) activity. Involved in response to furfural. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1519664..1520698, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative phenylacrylic acid decarboxylase FDC1 Neighboring gene Irc4p Neighboring gene seripauperin PAU10 Neighboring gene Y' element ATP-dependent helicase protein 1 copy 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Liu ZL, et al. Gene, 2009 Oct 1. PMID 19577617
  2. Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae. Moon J, et al. Yeast, 2015 Apr. PMID 25656103
  3. Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system. Delneri D, et al. Gene, 2000 Jul 11. PMID 10903444
  4. A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, et al. Nat Commun, 2020 Jul 3. PMID 32620756, Free PMC Article
  5. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YDR541C and YGL039W encoded an aldehyde reductase.
    Title: Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to furfural IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
carbonyl reductase (NADPH-dependent)
NP_010830.4
  • Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1519664..1520698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180849.4 → NP_010830.4  TPA: carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010830.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTG0, Q03049
    UniProtKB/TrEMBL
    N1PAM2
    Conserved Domains (1) summary
    cd05227
    Location:4 → 320
    AR_SDR_e; aldehyde reductase, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03049.2

Gene LinkOut

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