RTG3 Rtg3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RTG3
Official Full Name: Rtg3p
Primary source: SGD:S000000199
Locus tag: YBL103C
See related: AllianceGenome:SGD:S000000199; FungiDB:YBL103C; VEuPathDB:YBL103C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to oleic acid; mitochondria-nucleus signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor); TFEB (transcription factor EB); and TFEC (transcription factor EC). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RTG3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (22076..23536, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the function of Aup1 in mitophagy could be explained through its regulation of Rtg3-dependent transcription.
Title: Aup1-mediated regulation of Rtg3 during mitophagy.
Rtg1/3p, Gln3p, and Gat1p can be differentially regulated through different nutrient-sensing pathways, such as TOR and retrograde signaling, and by multiple factors, such as Lst8p, which is suggested to have a role in connecting the RTG and TOR pathways
Title: Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression.
Tor signaling and Mks1p phosphorylation regulate expression of Rtg1.Rtg3p-dependent target genes
Title: Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oleic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rtg3p

NP_009447.1

bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

22076..23536 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178343.1 → NP_009447.1 TPA: Rtg3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009447.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPQ0, P38165, P89494

UniProtKB/TrEMBL

B3LNN3, B5VDP2, C7GSE2, C8Z3T8, N1P7D1

Conserved Domains (1) summary

cd11387
Location:289 → 349

bHLHzip_USF_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family