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PIN4 Pin4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852229, updated on 9-Dec-2024

Summary

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Official Symbol
PIN4
Official Full Name
Pin4p
Primary source
SGD:S000000147
Locus tag
YBL051C
See related
AllianceGenome:SGD:S000000147; FungiDB:YBL051C; VEuPathDB:YBL051C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MDT1
Summary
Enables mRNA binding activity. Involved in DNA damage checkpoint signaling and G2/M transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PIN4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (122753..124759, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tod6p Neighboring gene histone acetyltransferase Neighboring gene Sec17p Neighboring gene Moh1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FHA domain-ligand interactions: importance of integrating chemical and biological approaches. Mahajan A, et al. J Am Chem Soc, 2005 Oct 26. PMID 16231900
  2. In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences. Burnside D, et al. iScience, 2019 Jan 25. PMID 30660105, Free PMC Article
  3. Prion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity. Yang Z, et al. Mol Microbiol, 2014 Sep. PMID 25039275, Free PMC Article
  4. Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Pike BL, et al. Mol Cell Biol, 2004 Apr. PMID 15024067, Free PMC Article
  5. Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae. Traven A, et al. Yeast, 2010 Jan. PMID 19894211

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of PIN4 Suppresses the Protein Transport Defects Caused by sec12-4 Mutation in Saccharomyces cerevisiae.
    Title: Deletion of PIN4 Suppresses the Protein Transport Defects Caused by sec12-4 Mutation in Saccharomyces cerevisiae.
  2. [PIN+] drives Pin4C into a toxic hyperphosphorylated species.
    Title: Prion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity.
  3. The results indicate that Mdt1 has partially separable functions in both cell wall and genome integrity pathways.
    Title: Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae.
  4. Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.
    Title: Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA damage checkpoint signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pin4p
NP_009502.1
  • Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    122753..124759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178291.1 → NP_009502.1  TPA: Pin4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009502.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPU8, P34217
    UniProtKB/TrEMBL
    N1P8R4
    Conserved Domains (2) summary
    cd02639
    Location:305 → 367
    R3H_RRM; R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1 ...
    cd12253
    Location:84 → 162
    RRM_PIN4_like; RNA recognition motif (RRM) found in yeast RNA-binding protein PIN4, fission yeast RNA-binding post-transcriptional regulators cip1, cip2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34217.1

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