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SEC17 Sec17p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852230, updated on 9-Dec-2024

Summary

Official Symbol
SEC17
Official Full Name
Sec17p
Primary source
SGD:S000000146
Locus tag
YBL050W
See related
AllianceGenome:SGD:S000000146; FungiDB:YBL050W; VEuPathDB:YBL050W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RNS3
Summary
Enables ATPase activator activity and soluble NSF attachment protein activity. Involved in SNARE complex disassembly; autophagy; and organelle fusion. Located in cytosol. Part of SNARE complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to several human genes including NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See SEC17 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (125125..126119)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase Neighboring gene Pin4p Neighboring gene Moh1p Neighboring gene Rrt1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables soluble NSF attachment protein activity IDA
Inferred from Direct Assay
more info
PubMed 
enables soluble NSF attachment protein activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in SNARE complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SNARE complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle fusion with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SNARE complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Sec17p
NP_009503.1
  • Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    125125..126119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178290.1NP_009503.1  TPA: Sec17p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009503.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPU9, P32602
    UniProtKB/TrEMBL
    A6ZKP8, B3LNI7, C7GNB4, C8Z3P9, G2W8V8, N1PAX3
    Conserved Domains (1) summary
    pfam14938
    Location:10284
    SNAP; Soluble NSF attachment protein, SNAP