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FUI1 uridine permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 852238, updated on 9-Dec-2024

Summary

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Official Symbol
FUI1
Official Full Name
uridine permease
Primary source
SGD:S000000138
Locus tag
YBL042C
See related
AllianceGenome:SGD:S000000138; FungiDB:YBL042C; VEuPathDB:YBL042C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables uridine transmembrane transporter activity. Involved in uridine transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FUI1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (138341..140260, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecm13p Neighboring gene proteasome core particle subunit beta 6 Neighboring gene Erd2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein. De Wergifosse P, et al. Yeast, 1994 Nov. PMID 7871888
  2. Characterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae. Zhang J, et al. J Biol Chem, 2006 Sep 22. PMID 16854981
  3. The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease. Wagner R, et al. FEMS Microbiol Lett, 1998 Feb 1. PMID 9485596
  4. Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Pinson B, et al. Biochem J, 1999 Apr 1. PMID 10085225, Free PMC Article
  5. Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Blondel MO, et al. Mol Biol Cell, 2004 Feb. PMID 14657252, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uridine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uridine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
uridine permease
NP_009511.1
  • High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    138341..140260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178282.1 → NP_009511.1  TPA: uridine permease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009511.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPV6, P38196
    UniProtKB/TrEMBL
    C7GNC0, G2W8W5, N1P8Z3
    Conserved Domains (1) summary
    cd11482
    Location:112 → 593
    SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38196.1

Gene LinkOut

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