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POP8 ribonuclease P [ Saccharomyces cerevisiae S288C ]

Gene ID: 852263, updated on 4-Jan-2025

Summary

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Official Symbol
POP8
Official Full Name
ribonuclease P
Primary source
SGD:S000000114
Locus tag
YBL018C
See related
AllianceGenome:SGD:S000000114; FungiDB:YBL018C; VEuPathDB:YBL018C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in intronic box C/D snoRNA processing; nuclear-transcribed mRNA catabolic process, RNase MRP-dependent; and tRNA processing. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See POP8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (185998..186474, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene glycolipid translocation protein Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene type I sorting receptor Neighboring gene mitogen-activated serine/threonine-protein kinase FUS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. Lu Q, et al. RNA, 2010 Mar. PMID 20086051, Free PMC Article
  2. In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Perederina A, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29722866, Free PMC Article
  3. Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Stohl LL, et al. Mol Cell Biol, 1992 Jun. PMID 1588958, Free PMC Article
  4. Yeast RNase P: catalytic activity and substrate binding are separate functions. Nichols M, et al. Proc Natl Acad Sci U S A, 1988 Mar. PMID 3278310, Free PMC Article
  5. Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P. Thomas BC, et al. RNA, 2000 Apr. PMID 10786846, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease MRP activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease P activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intronic box C/D snoRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intronic box C/D snoRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleolar ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease P
NP_009535.1
  • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    185998..186474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178258.1 → NP_009535.1  TPA: ribonuclease P [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009535.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPY2, P38208
    UniProtKB/TrEMBL
    A6ZKT0, C8Z3X8, G2W8Z1, N1P907
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38208.1

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