CSG2 mannosylinositol phosphorylceramide synthase regulatory subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CSG2
Official Full Name: mannosylinositol phosphorylceramide synthase regulatory subunit
Primary source: SGD:S000000240
Locus tag: YBR036C
See related: AllianceGenome:SGD:S000000240; FungiDB:YBR036C; VEuPathDB:YBR036C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CLS2
Summary: Enables enzyme regulator activity and intracellularly gated calcium channel activity. Involved in endoplasmic reticulum calcium ion homeostasis; glycosphingolipid biosynthetic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in endoplasmic reticulum and fungal-type vacuole. Is active in endoplasmic reticulum membrane. Used to study Charcot-Marie-Tooth disease. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CSG2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (309081..310313, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
Title: The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannosylinositol phosphorylceramide synthase regulatory subunit

NP_009592.1

Calcium release channel involved in ER calcium homeostasis; integrates ER calcium release with the regulation of sphingolipid metabolism and autophagy; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; endoplasmic reticulum membrane protein; contains 10 transmembrane domains and a potential Ca2+ EF-hand motif; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

309081..310313 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178384.1 → NP_009592.1 TPA: mannosylinositol phosphorylceramide synthase regulatory subunit [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009592.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ36, P35206

UniProtKB/TrEMBL

A6ZKY0, B3LNA9, B5VE02, C7GXX6, D3UED2, N1P9C8

Conserved Domains (1) summary

pfam16965
Location:1 → 403

CSG2; Ceramide synthase regulator