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ECM2 Ecm2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852357, updated on 9-Dec-2024

Summary

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Official Symbol
ECM2
Official Full Name
Ecm2p
Primary source
SGD:S000000269
Locus tag
YBR065C
See related
AllianceGenome:SGD:S000000269; FungiDB:YBR065C; VEuPathDB:YBR065C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLT11
Summary
Enables U6 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECM2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (368584..369678, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cnm1p Neighboring gene Nrg2p Neighboring gene putative lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome. Xu D, et al. Mol Cell Biol, 2001 Feb. PMID 11158289, Free PMC Article
  2. Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2. Yang H, et al. Nat Commun, 2015 Feb 6. PMID 25655993
  3. Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing. van der Feltz C, et al. RNA, 2021 Feb 5. PMID 33547186, Free PMC Article
  4. Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Xu D, et al. Mol Cell Biol, 1998 Apr. PMID 9528778, Free PMC Article
  5. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ecm2p
NP_009621.3
  • Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    368584..369678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178413.3 → NP_009621.3  TPA: Ecm2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009621.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ64, P38241, P89497
    UniProtKB/TrEMBL
    A6ZL09, B3LN84, C7GQI0, G2W970, N1PAS0
    Conserved Domains (1) summary
    cd12265
    Location:201 → 295
    RRM_SLT11; RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38241.1

Gene LinkOut

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