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ECM33 Ecm33p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852370, updated on 9-Dec-2024

Summary

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Official Symbol
ECM33
Official Full Name
Ecm33p
Primary source
SGD:S000000282
Locus tag
YBR078W
See related
AllianceGenome:SGD:S000000282; FungiDB:YBR078W; VEuPathDB:YBR078W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fungal-type cell wall organization. Located in fungal-type cell wall and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECM33 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (393123..394742)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ecm8p Neighboring gene Slm4p Neighboring gene translation initiation factor eIF3 core subunit a Neighboring gene AAA family ATPase SEC18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Cell surface protein Ecm33 is involved in negative feedback regulation of MAP kinase signalling and development of the in vivo real-time monitoring of MAP kinase signalling]. Takada H. Yakugaku Zasshi, 2011. PMID 21804323
  2. Ecm33 is a novel factor involved in efficient glucose uptake for nutrition-responsive TORC1 signaling in yeast. Umekawa M, et al. FEBS Lett, 2017 Nov. PMID 29029364
  3. Disruption of the cell wall integrity gene ECM33 results in improved fermentation by wine yeast. Zhang J, et al. Metab Eng, 2018 Jan. PMID 29289724
  4. Engineering Cell Wall Integrity Enables Enhanced Squalene Production in Yeast. Son SH, et al. J Agric Food Chem, 2020 Apr 29. PMID 32266810
  5. Disruption of ECM33 in diploid wine yeast EC1118: cell morphology and aggregation and their influence on fermentation performance. Lang TA, et al. FEMS Yeast Res, 2021 Aug 13. PMID 34355770

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of the cell wall protein Ecm33p in yeast Saccharomyces cerevisiae improves the production of small metabolites.
    Title: Modulation of the cell wall protein Ecm33p in yeast Saccharomyces cerevisiae improves the production of small metabolites.
  2. Study shows that Ecm33 is involved in regulating intracellular TORC1 signaling by facilitating efficient uptake of extracellular glucose, the most vital nutrient.
    Title: Ecm33 is a novel factor involved in efficient glucose uptake for nutrition-responsive TORC1 signaling in yeast.
  3. Ecm33 overproducing cells displayed phenotypes closely similar to those of the pmk1 knockout cell[review]
    Title: [Cell surface protein Ecm33 is involved in negative feedback regulation of MAP kinase signalling and development of the in vivo real-time monitoring of MAP kinase signalling].
  4. important for proper cell wall ultrastructure organization and, for the correct assembly of the mannoprotein outer layer of the cell wall.
    Title: PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ecm33p
NP_009634.2
  • GPI-anchored protein involved in efficient glucose uptake; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    393123..394742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178426.2 → NP_009634.2  TPA: Ecm33p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009634.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ77, P38248, P89498
    UniProtKB/TrEMBL
    G2W983, N1PAS3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38248.3

Gene LinkOut

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