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CBP6 Cbp6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852417, updated on 9-Dec-2024

Summary

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Official Symbol
CBP6
Official Full Name
Cbp6p
Primary source
SGD:S000000324
Locus tag
YBR120C
See related
AllianceGenome:SGD:S000000324; FungiDB:YBR120C; VEuPathDB:YBR120C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ribosome binding activity. Involved in mitochondrial respiratory chain complex III assembly and positive regulation of mitochondrial translation. Located in mitochondrial ribosome. Part of Cbp3p-Cbp6 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CBP6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (480435..480923, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Mud1p Neighboring gene glycine--tRNA ligase Neighboring gene mitochondrial 54S ribosomal protein YmL36

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b. Dieckmann CL, et al. J Biol Chem, 1985 Feb 10. PMID 2981859
  2. Mutational analysis of yeast mitochondrial translational activator Cbs2p and of YHR063Cp, a protein with similarity to Cbs2p. Tzschoppe K, et al. Curr Genet, 1999 Oct. PMID 10541857
  3. Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly. Ndi M, et al. J Biol Chem, 2019 Nov 8. PMID 31537648, Free PMC Article
  4. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, et al. J Cell Biol, 2011 Jun 13. PMID 21670217, Free PMC Article
  5. Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis. Kühl I, et al. Mitochondrion, 2012 May. PMID 22349564, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that the essential role of Cbp3 and Cbp6 is to assist Cytb hemylation and demonstrate that in the absence of heme b, Cytb can form non-functional supercomplexes with cytochrome c oxidase.
    Title: Cbp3 and Cbp6 are dispensable for synthesis regulation of cytochrome b in yeast mitochondria.
  2. Cbp3-Cbp6 also coordinates cytochrome b synthesis with bc(1) complex assembly.
    Title: The Cbp3-Cbp6 complex coordinates cytochrome b synthesis with bc(1) complex assembly in yeast mitochondria.
  3. Results suggest that synthesis of cytochrome b occurs preferentially on those ribosomes that have the Cbp3-Cbp6 complex bound to their tunnel exit, an arrangement that may ensure tight coordination of cytochrome b synthesis and assembly.
    Title: Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex III assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cbp3p-Cbp6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cbp3p-Cbp6 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cbp3p-Cbp6 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cbp6p
NP_009678.3
  • Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    480435..480923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178468.3 → NP_009678.3  TPA: Cbp6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009678.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQB8, E9P8V5, P07253
    UniProtKB/TrEMBL
    A6ZL65, B3LN35, B5VE80, C7GY05, G2W9C5, N1P6N6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07253.1

Gene LinkOut

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