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Pola2 DNA polymerase alpha 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 85242, updated on 27-Nov-2024

Summary

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Official Symbol
Pola2provided by RGD
Official Full Name
DNA polymerase alpha 2, accessory subunitprovided by RGD
Primary source
RGD:621817
See related
EnsemblRapid:ENSRNOG00000020906 AllianceGenome:RGD:621817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA-directed DNA polymerase activity. Involved in DNA replication. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 81.3), Thymus (RPKM 73.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pola2 in Genome Data Viewer
Location:
1q43
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212656500..212680667, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203227183..203251350, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221297417..221321601, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 2 Neighboring gene 40S ribosomal protein S27-like Neighboring gene solute carrier family 22 member 20 Neighboring gene calpain 1 Neighboring gene uncharacterized LOC108349685

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, et al. Mol Carcinog, 2001 Aug. PMID 11536367
  2. The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha. Mizuno T, et al. Mol Cell Biol, 1998 Jun. PMID 9584195, Free PMC Article
  3. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. López-Girona A, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503737
  4. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ. Baranovskiy AG, et al. J Biol Chem, 2012 May 18. PMID 22465957, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IC
Inferred by Curator
more info
 PubMed 
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
  
part_of alpha DNA polymerase:primase complex ISO
Inferred from Sequence Orthology
more info
  
part_of alpha DNA polymerase:primase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of alpha DNA polymerase:primase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase alpha subunit B
Names
DNA polymerase alpha 70 kDa subunit
DNA polymerase alpha subunit II
DNA polymerase subunit II
DNA-directed DNA polymerase alpha 2
polymerase (DNA directed), alpha 2, accessory subunit
polymerase (DNA) alpha 2, accessory subunit
NP_445932.2
XP_038948828.1
XP_038948832.1
XP_063131945.1
XP_063131954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053480.2 → NP_445932.2  DNA polymerase alpha subunit B

    See identical proteins and their annotated locations for NP_445932.2

    Status: PROVISIONAL

    Source sequence(s)
    BC097300
    UniProtKB/TrEMBL
    A6HZB5, G3V8U6, Q4V8M9
    Related
    ENSRNOP00000028406.3, ENSRNOT00000028406.6
    Conserved Domains (2) summary
    pfam04042
    Location:343 → 549
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:20 → 238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212656500..212680667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092904.2 → XP_038948832.1  DNA polymerase alpha subunit B isoform X4

    Conserved Domains (1) summary
    pfam04042
    Location:56 → 262
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

  2. XM_063275884.1 → XP_063131954.1  DNA polymerase alpha subunit B isoform X2

  3. XM_063275875.1 → XP_063131945.1  DNA polymerase alpha subunit B isoform X1

  4. XM_039092900.2 → XP_038948828.1  DNA polymerase alpha subunit B isoform X3

    Conserved Domains (2) summary
    COG5214
    Location:206 → 411
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    pfam08418
    Location:21 → 238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

RNA

  1. XR_010058450.1 RNA Sequence

  2. XR_001835495.3 RNA Sequence

  3. XR_005493542.2 RNA Sequence

  4. XR_005493528.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89043.2 GenPept UniProtKB/Swiss-Prot:O89043

Gene LinkOut

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