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PTC4 type 2C protein phosphatase PTC4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852422, updated on 9-Dec-2024

Summary

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Official Symbol
PTC4
Official Full Name
type 2C protein phosphatase PTC4
Primary source
SGD:S000000329
Locus tag
YBR125C
See related
AllianceGenome:SGD:S000000329; FungiDB:YBR125C; VEuPathDB:YBR125C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GCT1
Summary
Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PTC4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (487199..488380, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL36 Neighboring gene transcription factor TFIIIC subunit TFC1 Neighboring gene alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 Neighboring gene Meo1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae. Lee JW, et al. Sci Rep, 2021 Dec 17. PMID 34921163, Free PMC Article
  2. Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae. Sharmin D, et al. Yeast, 2014 Oct. PMID 25088474
  3. Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae. Shitamukai A, et al. J Biol Chem, 2004 Jan 30. PMID 14583627
  4. A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Sakumoto N, et al. Yeast, 1999 Nov. PMID 10572263
  5. Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Cheng A, et al. Genes Dev, 1999 Nov 15. PMID 10580002, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
    Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
type 2C protein phosphatase PTC4
NP_009683.1
  • Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    487199..488380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178473.1 → NP_009683.1  TPA: type 2C protein phosphatase PTC4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC2, P38089
    UniProtKB/TrEMBL
    A6ZL69, B3LN31, B5VE84, C7GY08, D3UEL7, G2W9C9, N1P6P0
    Conserved Domains (1) summary
    pfam00481
    Location:82 → 355
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38089.1

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