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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852434, updated on 9-Dec-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000000341
Locus tag
YBR137W
See related
AllianceGenome:SGD:S000000341; FungiDB:YBR137W; VEuPathDB:YBR137W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in post-translational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm. Part of TRC complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (513044..513583)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein kinase regulatory subunit CKS1 Neighboring gene protein kinase MEC1 Neighboring gene uncharacterized protein Neighboring gene carboxypeptidase C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes. Yeh YH, et al. Mol Cell Biol, 2014 Dec. PMID 25288638, Free PMC Article
  2. Disruption of six novel yeast genes located on chromosome II reveals one gene essential for vegetative growth and two required for sporulation and conferring hypersensitivity to various chemicals. Kucharczyk R, et al. Yeast, 1999 Jul. PMID 10407278
  3. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. Yoshida K, et al. J Cell Biol, 2001 Feb 19. PMID 11266464, Free PMC Article
  4. Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins. Kohl C, et al. Biol Chem, 2011 Jul. PMID 21619481
  5. A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum. Wang F, et al. Mol Cell, 2010 Oct 8. PMID 20850366, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to endoplasmic reticulum membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRC complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_009695.2
  • Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    513044..513583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178485.2 → NP_009695.2  TPA: uncharacterized protein YBR137W [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009695.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQD3, P38276
    UniProtKB/TrEMBL
    A6ZL80, B3LN20, C7GY19, D3UEN1, G2W9E0, N1P9H4
    Conserved Domains (1) summary
    COG4702
    Location:9 → 179
    COG4702; Uncharacterized protein, UPF0303 family [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38276.4

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