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FTH1 Fth1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852506, updated on 9-Dec-2024

Summary

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Official Symbol
FTH1
Official Full Name
Fth1p
Primary source
SGD:S000000411
Locus tag
YBR207W
See related
AllianceGenome:SGD:S000000411; FungiDB:YBR207W; VEuPathDB:YBR207W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Involved in endocytosis and iron ion transmembrane transport. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FTH1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (635146..636543)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene mannosyltransferase KTR3 Neighboring gene bifunctional urea carboxylase/allophanate hydrolase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane. Urbanowski JL, et al. J Biol Chem, 1999 Dec 31. PMID 10608875
  2. Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. Yamaguchi-Iwai Y, et al. EMBO J, 1996 Jul 1. PMID 8670839, Free PMC Article
  3. Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae. Singh A, et al. J Biol Chem, 2006 May 12. PMID 16522632
  4. ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation. Yang X, et al. J Cell Biol, 2021 Aug 2. PMID 34047770, Free PMC Article
  5. Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion. McNally EK, et al. Dev Cell, 2017 Jan 23. PMID 28017618

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of high-affinity iron permease complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of high-affinity iron permease complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fth1p
NP_009766.4
  • Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    635146..636543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178555.4 → NP_009766.4  TPA: Fth1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009766.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK4, P38310, Q9URQ1
    UniProtKB/TrEMBL
    A6ZLE8, B3LMV2, B5VEF8, C7GKG9, D3UEV4, G2W9L1, N1P9K5
    Conserved Domains (1) summary
    COG0672
    Location:2 → 465
    FTR1; High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38310.2

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