MET8 bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET8
Official Full Name: bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
Primary source: SGD:S000000417
Locus tag: YBR213W
See related: AllianceGenome:SGD:S000000417; FungiDB:YBR213W; VEuPathDB:YBR213W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferrochelatase activity and precorrin-2 dehydrogenase activity. Involved in siroheme biosynthetic process and sulfate assimilation. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET8 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (650368..651192)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferrochelatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrochelatase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables precorrin-2 dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables precorrin-2 dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables precorrin-2 dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables sirohydrochlorin ferrochelatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in siroheme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in siroheme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in siroheme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate assimilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8

NP_009772.1

EC 1.3.1.76

EC 4.99.1.4

Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

650368..651192

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178561.1 → NP_009772.1 TPA: bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009772.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQK9, P15807

UniProtKB/TrEMBL

G2W9L6

Conserved Domains (1) summary

COG1648
Location:2 → 254

CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]