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SWC5 Swc5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852532, updated on 5-Jan-2025

Summary

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Official Symbol
SWC5
Official Full Name
Swc5p
Primary source
SGD:S000000435
Locus tag
YBR231C
See related
AllianceGenome:SGD:S000000435; FungiDB:YBR231C; VEuPathDB:YBR231C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AOR1
Summary
Involved in chromatin remodeling. Located in cytosol and nucleus. Part of Swr1 complex. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SWC5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (682179..683090, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Coq21p Neighboring gene ncRNA Neighboring gene Pbp2p Neighboring gene Dad3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells. Mohan C, et al. Elife, 2018 Aug 9. PMID 30091702, Free PMC Article
  2. Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing. Huang Y, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32001508, Free PMC Article
  3. Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B. Chu WT, et al. Proteins, 2021 May. PMID 33320380
  4. Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C. Baier AS, et al. Elife, 2024 May 29. PMID 38809771, Free PMC Article
  5. The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z. Morillo-Huesca M, et al. PLoS One, 2010 Aug 12. PMID 20711347, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
    Title: Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
  2. Swc5 uses a tandem DEF/Y motif facilitate transcription by replacing the two nucleosomal H2A-H2B (A-B) dimers with H2A.Z-H2B (Z-B) dimers.
    Title: Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing.
  3. Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction has been reported.
    Title: Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Swc5p
NP_009790.3
  • Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    682179..683090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178579.3 → NP_009790.3  TPA: Swc5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009790.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQM7, P38326
    UniProtKB/TrEMBL
    A6ZLH0, C7GMS2, D3UEX8, G2W9N4
    Conserved Domains (1) summary
    pfam07572
    Location:233 → 286
    BCNT; Bucentaur or craniofacial development
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38326.1

Gene LinkOut

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