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THI2 Thi2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852542, updated on 4-Jan-2025

Summary

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Official Symbol
THI2
Official Full Name
Thi2p
Primary source
SGD:S000000444
Locus tag
YBR240C
See related
AllianceGenome:SGD:S000000444; FungiDB:YBR240C; VEuPathDB:YBR240C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PHO6
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of thiamine biosynthetic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See THI2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (700490..701842, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ert1p Neighboring gene Vvs1p Neighboring gene 5'-deoxynucleotidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characteristics of a positive regulatory gene, THI2 (PHO6), of thiamin biosynthesis in Saccharomyces cerevisiae. Nishimura H, et al. FEBS Lett, 1992 Feb 3. PMID 1551422
  2. Two new genes controlling the constitutive acid phosphatase synthesis in Saccharomyces cerevisiae. Toh-e A, et al. Mol Gen Genet, 1975 Nov 3. PMID 765726
  3. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. Nosaka K, et al. J Biol Chem, 1994 Dec 2. PMID 7982968
  4. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Nosaka K, et al. Mol Microbiol, 2005 Oct. PMID 16194233
  5. Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. Iosue CL, et al. PLoS One, 2016. PMID 27015653, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of thiamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thi2p
NP_009799.3
  • Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    700490..701842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178588.3 → NP_009799.3  TPA: Thi2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009799.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQN6, P38141
    UniProtKB/TrEMBL
    A6ZLH9, B3LMS2, B5VEJ0, C7GMT4, D3UEY8, G2W9P3, N1P8J0
    Conserved Domains (1) summary
    pfam00172
    Location:28 → 66
    Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38141.1

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