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TAE1 N-terminal protein methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852564, updated on 9-Dec-2024

Summary

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Official Symbol
TAE1
Official Full Name
N-terminal protein methyltransferase
Primary source
SGD:S000000465
Locus tag
YBR261C
See related
AllianceGenome:SGD:S000000465; FungiDB:YBR261C; VEuPathDB:YBR261C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NTM1
Summary
Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal peptidyl-proline dimethylation and cytoplasmic translation. Located in cytosol. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) and NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TAE1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (734832..735530, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein RGD1 Neighboring gene Mic12p Neighboring gene glycine hydroxymethyltransferase SHM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovering the N-Terminal Methylome by Repurposing of Proteomic Datasets. Chen P, et al. J Proteome Res, 2021 Sep 3. PMID 34382793
  2. Identification of protein N-terminal methyltransferases in yeast and humans. Webb KJ, et al. Biochemistry, 2010 Jun 29. PMID 20481588, Free PMC Article
  3. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
  4. Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis. Alamgir M, et al. BMC Genomics, 2008 Dec 3. PMID 19055778, Free PMC Article
  5. DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA. Jagadeesan SK, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675300, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. deletion of YBR261C alters the ribosomal profile of the mutant cells. Also, gene deletion strain for YBR261C has defects in both translation efficiency and fidelity
    Title: Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-terminal protein N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-terminal protein N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-terminal protein N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-proline dimethylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-terminal peptidyl-proline dimethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-terminal protein methyltransferase
NP_009820.1
  • AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    734832..735530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178609.1 → NP_009820.1  TPA: N-terminal protein methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQQ8, P38340
    UniProtKB/TrEMBL
    A6ZLK1, B3LMQ0, B5VEL0, C7GMW9, D3UF09, G2W9R6, N1P8T9
    Conserved Domains (1) summary
    pfam05891
    Location:6 → 228
    Methyltransf_PK; AdoMet dependent proline di-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38340.1

Gene LinkOut

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