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BIT2 Bit2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852573, updated on 9-Dec-2024

Summary

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Official Symbol
BIT2
Official Full Name
Bit2p
Primary source
SGD:S000000474
Locus tag
YBR270C
See related
AllianceGenome:SGD:S000000474; FungiDB:YBR270C; VEuPathDB:YBR270C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in TORC2 signaling. Part of TORC2 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BIT2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (742761..744398, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL37 Neighboring gene Sdh8p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Hsm3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TOR2 is required for organization of the actin cytoskeleton in yeast. Schmidt A, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943012, Free PMC Article
  2. Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Gaubitz C, et al. Mol Cell, 2015 Jun 18. PMID 26028537
  3. The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Fadri M, et al. Mol Biol Cell, 2005 Apr. PMID 15689497, Free PMC Article
  4. Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics. Daniel J. Yeast, 2007 Jul. PMID 17533620
  5. Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Cagney G, et al. Physiol Genomics, 2001 Oct 10. PMID 11595789

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bit2p
NP_009829.2
  • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    742761..744398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178618.2 → NP_009829.2  TPA: Bit2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009829.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQR6, P38346
    UniProtKB/TrEMBL
    B3LMP2, N1PAW4
    Conserved Domains (1) summary
    pfam08539
    Location:326 → 482
    HbrB; HbrB-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38346.2

Gene LinkOut

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