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EMC4 chaperone EMC4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852620, updated on 9-Dec-2024

Summary

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Official Symbol
EMC4
Official Full Name
chaperone EMC4
Primary source
SGD:S000003200
Locus tag
YGL231C
See related
AllianceGenome:SGD:S000003200; FungiDB:YGL231C; VEuPathDB:YGL231C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EMC4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (63048..63620, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rab GTPase-binding exocyst subunit SEC15 Neighboring gene putative tRNA acetyltransferase Neighboring gene uncharacterized protein Neighboring gene Sap4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. Ring G, et al. FEBS Lett, 2008 Jul 23. PMID 18586032
  2. Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions. Sharma S, et al. J Genet Eng Biotechnol, 2020 Jun 1. PMID 32476094, Free PMC Article
  3. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  4. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
  5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of the yeast TMEM85 ortholog YGL231c leads to increased resistance to oxidative stress.
    Title: Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding in endoplasmic reticulum HGI PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chaperone EMC4
NP_011283.1
  • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    63048..63620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181097.1 → NP_011283.1  TPA: chaperone EMC4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVA3, P53073
    UniProtKB/TrEMBL
    A6ZTV9, B3LHS4, B5VIB2, C7GNX8, C8Z824, G2WDM8, N1P3W9
    Conserved Domains (1) summary
    pfam06417
    Location:60 → 176
    DUF1077; Protein of unknown function (DUF1077)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53073.1

Gene LinkOut

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