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SAP4 Sap4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852622, updated on 9-Dec-2024

Summary

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Official Symbol
SAP4
Official Full Name
Sap4p
Primary source
SGD:S000003198
Locus tag
YGL229C
See related
AllianceGenome:SGD:S000003198; FungiDB:YGL229C; VEuPathDB:YGL229C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein phosphatase regulator activity. Involved in G1/S transition of mitotic cell cycle. Located in mitochondrion. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SAP4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (64503..66959, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene chaperone EMC4 Neighboring gene uncharacterized protein Neighboring gene She10p Neighboring gene glucose-induced degradation complex subunit VID30

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
  2. Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions. Sharma S, et al. J Genet Eng Biotechnol, 2020 Jun 1. PMID 32476094, Free PMC Article
  3. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke MM, et al. Mol Cell Biol, 1996 Jun. PMID 8649382, Free PMC Article
  4. Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by rapamycin and zymocin. Jablonowski D, et al. Eukaryot Cell, 2009 Nov. PMID 19749176, Free PMC Article
  5. The serine/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae. Miranda MN, et al. FEMS Yeast Res, 2010 Sep. PMID 20608983

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sap4p
NP_011285.1
  • Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    64503..66959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181095.1 → NP_011285.1  TPA: Sap4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011285.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVA5, P53036
    UniProtKB/TrEMBL
    A6ZTW1
    Conserved Domains (1) summary
    pfam04499
    Location:207 → 736
    SAPS; SIT4 phosphatase-associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53036.1

Gene LinkOut

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