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VRG4 GDP-mannose transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 852647, updated on 9-Dec-2024

Summary

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Official Symbol
VRG4
Official Full Name
GDP-mannose transporter
Primary source
SGD:S000003193
Locus tag
YGL225W
See related
AllianceGenome:SGD:S000003193; FungiDB:YGL225W; VEuPathDB:YGL225W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GOG5; LDB3; VAN2; VIG4
Summary
Enables GDP-mannose transmembrane transporter activity. Involved in GDP-mannose transmembrane transport. Located in Golgi apparatus. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VRG4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (76894..77907)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtc3p Neighboring gene tRNA-Val Neighboring gene nucleotidase Neighboring gene Golgi transport complex subunit COG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast VRG4 gene is required for normal Golgi functions and defines a new family of related genes. Poster JB, et al. J Biol Chem, 1996 Feb 16. PMID 8632002
  2. Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. Parker JL, et al. Nat Commun, 2019 Oct 11. PMID 31604945, Free PMC Article
  3. Molecular characterization of Vig4/Vrg4 GDP-mannose transporter of the yeast Saccharomyces cerevisiae. Abe M, et al. FEBS Lett, 1999 Sep 24. PMID 10570930
  4. Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum. Gao XD, et al. J Biol Chem, 2000 Jun 9. PMID 10748175
  5. Identification of a conserved motif in the yeast golgi GDP-mannose transporter required for binding to nucleotide sugar. Gao XD, et al. J Biol Chem, 2001 Feb 9. PMID 11067855

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GDP-mannose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-mannose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-mannose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
GDP-mannose transporter
NP_011290.1
  • Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    76894..77907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181090.1 → NP_011290.1  TPA: GDP-mannose transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011290.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZTW6, B3LHR7, C7GUZ7, C8Z830, D6VVB0, P40107
    UniProtKB/TrEMBL
    G2WDN6, N1P2D2
    Conserved Domains (1) summary
    COG5070
    Location:15 → 337
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40107.1

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